Facile da capire Cosmico complemento h3b 8800 clinical trial Allombra frequentemente Fermati a sapere
Reprogramming RNA processing: an emerging therapeutic landscape: Trends in Pharmacological Sciences
David Steensma, MD on Twitter: "#H3B-8800 #SF3B1 inhibitor #MDS #AML Phase 1; we treated 81 patients and defined MTD as 30 mg 5d on 9 day off schedule and saw deep modulation
RVT-2001 / Eisai, Roivant
Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B -8800 in myeloid neoplasms | Leukemia
A Comprehensive Overview of Structure‐Activity Relationships of Small‐Molecule Splicing Modulators Targeting SF3B1 as Anticancer Agents - Zhang - 2020 - ChemMedChem - Wiley Online Library
Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation - ScienceDirect
Tweets with replies by Dan Wiseman (@dwiseman78) / Twitter
H3B-8800 | Chemistry Information PDF | PharmaCompass.com
IJMS | Free Full-Text | Molecular Targeted Therapy and Immunotherapy for Myelodysplastic Syndrome | HTML
Therapeutic approaches to treat human spliceosomal diseases. - Abstract - Europe PMC
SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia | Leukemia
PHASE I DOSE ESCALATION CLINICAL TRIAL OF H3B-8800, A SPLICING.... EHA Library. Steensma D. Jun 15 2019; 266651
Science | H3 Biomedicine
IJMS | Free Full-Text | Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers | HTML
FDA accepts H3 Biomedicine's IND application to start phase 1 trials for oncology drug candidate H3B-8800 | Global Pharma Update
Production of novel pladienolide analogues through native expression of a pathway-specific activator - Chemical Science (RSC Publishing) DOI:10.1039/D0SC01928C
Aberrant RNA splicing and therapeutic opportunities in cancers - Yamauchi - 2022 - Cancer Science - Wiley Online Library